Connection

Announcement

You can now add alternative names! Click here to add other names that you've published under.

Search Results to Robert Reis

This is a "connection" page, showing the details of why an item matched the keywords from your search.

Search Results

Reis, Robert

One or more keywords matched the following properties of Reis, Robert

Property

Value

overview

My research group has been focused for the last 5 years on two areas: (1.) the role of PI 3-kinase in insulin-like signaling and extreme longevity, extending to a 10-fold increase in lifespan for C. elegans nematodes carrying a null mutation; and (2.) protein aggregation as a unifying feature of many or all age-progressive diseases. We have pursued specific aggregate proteins that favor the formation of aggregates (by promoting protein coallescence) or disrupt their clearance (through interference with proteasomes and autophagosomes). We use proteomics to identify proteins in aggregates of Alzheimer's and other human neurodegenerative diseases; their known or predicted structures allow molecular-dynamic simulations of protein-protein and protein-drug interactions. Predictions from in silico studies are then tested in vivo using models of Alzheimer’s and other human neurodegenerative diseases, in the nematode C. elegans, in cultured human cells, and in mouse models of neuropathy. Molecular genetics and bioinformatics provide complementary tools to discover and understand functional interactions. Water under the bridge (previous research): From the start of my research career, I have been fascinated by the genetic regulation of longevity and age-associated diseases. My group characterized a number of mutations that have large effects on lifespan in the nematode C. elegans. We also used gene mapping combined with bioinformatics approaches to discover and characterize the natural variation in genes that modulate lifespan. We found that Rec-8 protein (a cohesin) alters lifespan in nematodes and yeast, and a colleague then showed that it also contributed to the exceptional longevity of bowhead whales. In mammalian genetics, we were the first to identify the Pirin gene on the X chromosome as a determinant of post-menopausal bone loss in women, a discovery subsequently confirmed in a Chinese population. We also pioneered studies of homologous recombination (HR) and its roles in the etiology and subsequent progression of myeloma, prostate and breast cancers. Data from our laboratory, and subsequently many others, support the hypothesis that HR generates genetic diversity from which more highly oncogenic clones emerge by cell selection. We have exploited the heavy dependence of cancer cells on HR to develop synergistic combinations of chemotherapeutic drugs.

One or more keywords matched the following items that are connected to Reis, Robert

Item Type	Name
Concept	Protein Conformation
Concept	Protein Binding
Concept	Protein Multimerization
Concept	Protein Folding
Concept	Protein Unfolding
Concept	Protein Biosynthesis
Concept	Protein Structure, Secondary
Academic Article	Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes.
Academic Article	Age- and Hypertension-Associated Protein Aggregates in Mouse Heart Have Similar Proteomic Profiles.
Academic Article	Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls.
Academic Article	PIP3-binding proteins promote age-dependent protein aggregation and limit survival in C. elegans.
Academic Article	Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans.
Academic Article	Ribosomes from aging mice are not generally deficient in cell-free protein synthesis.
Academic Article	Aspirin-Mediated Acetylation Protects Against Multiple Neurodegenerative Pathologies by Impeding Protein Aggregation.
Academic Article	Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs.
Academic Article	ALS-causing mutations in profilin-1 alter its conformational dynamics: A computational approach to explain propensity for aggregation.
Academic Article	Structural insights into pro-aggregation effects of C. elegans CRAM-1 and its human ortholog SERF2.
Grant	Early Events in Alzheimer Pathogenesis
Grant	Arkansas Claude Pepper Older Americans Independence Center at UAMS
Grant	Roles of protein aggregation in Alzheimer’s and other neurodegenerative diseases
Academic Article	Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases.
Academic Article	A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer's Disease.
Academic Article	Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of A? Self-Aggregation and Metal Chelation-Induced A? Aggregation.
Academic Article	Structural modeling of GSK3? implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs.
Academic Article	Interaction of adeno-associated virus Rep78 with SV40 T antigen: implications in Rep protein expression leading to the inhibition of SV40-mediated cell proliferation.
Academic Article	"Protein aggregates" contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation.
Academic Article	Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer's disease.
Academic Article	Label-free photothermal disruption of cytotoxic aggregates rescues pathology in a C. elegans model of Huntington's disease.
Academic Article	Glial Fibrillary Acidic Protein: A Biomarker and Drug Target for Alzheimer's Disease.
Academic Article	Protein homeostasis in the aged and diseased heart.
Academic Article	In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration.
Academic Article	Myocardial infarction elevates endoplasmic reticulum stress and protein aggregation in heart as well as brain.

Search Criteria

Protein C